The Kigali amendment to the Montreal Protocol will require the phase out of R410A used in air conditioning systems in developed countries by the late 2020s. The HVAC&R industry will therefore need to begin using R410A replacements by the mid 2020s. Alternatives for R410A with lower global warming potentials (GWP) have been studied extensively over the past few years with limited success in finding an optimal replacement. A number of near design-compatible candidates (close match in capacity, efficiency, and other factors) have been proposed and evaluated, including R32, R452B, R454B, HPR2A, ARM-71a, and R447B. These fluids are all classified as “2L” flammable.This paper reports the characteristics and performance of a new and innovative R410A alternative in two air conditioning platforms. System performance measurements with this new refrigerant are presented for a 100 RT air-cooled packaged water chiller along with R410A as baseline, as well as R32 and R452B. The chiller comprised scroll compressors, a brazed plate evaporator, and microchannel condenser. Also, system performance results with the new refrigerant are presented for a 3 RT residential split system along with R410A as baseline. The new refrigerant was designed to be compatible with existing R-410A equipment, requiring minimal modifications to equipment for air conditioning and heat pump applications.